STT3B

Protein-coding gene in the species Homo sapiens
STT3B
Identifiers
AliasesSTT3B, CDG1X, SIMP, STT3-B, catalytic subunit of the oligosaccharyltransferase complex, STT3 oligosaccharyltransferase complex catalytic subunit B
External IDsOMIM: 608605; MGI: 1915542; HomoloGene: 7387; GeneCards: STT3B; OMA:STT3B - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for STT3B
Genomic location for STT3B
Band3p23Start31,532,638 bp[1]
End31,637,616 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for STT3B
Genomic location for STT3B
Band9|9 F3Start115,071,649 bp[2]
End115,139,489 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • cardiac muscle tissue of right atrium

  • skin of arm

  • corpus epididymis

  • myocardium of left ventricle

  • thymus

  • Achilles tendon

  • retinal pigment epithelium

  • caput epididymis

  • tibialis anterior muscle
Top expressed in
  • seminal vesicula

  • transitional epithelium of urinary bladder

  • lacrimal gland

  • human fetus

  • migratory enteric neural crest cell

  • calvaria

  • epithelium of stomach

  • vas deferens

  • molar

  • left colon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • oligosaccharyl transferase activity
  • dolichyl-diphosphooligosaccharide-protein glycotransferase activity
  • glycosyltransferase activity
  • metal ion binding
  • protein binding
Cellular component
  • integral component of membrane
  • oligosaccharyltransferase complex
  • endoplasmic reticulum
  • membrane
  • endoplasmic reticulum membrane
  • protein-containing complex
  • oligosaccharyltransferase I complex
Biological process
  • post-translational protein modification
  • protein glycosylation
  • co-translational protein modification
  • response to unfolded protein
  • protein N-linked glycosylation via asparagine
  • ubiquitin-dependent ERAD pathway
  • glycoprotein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

201595

68292

Ensembl

ENSG00000163527

ENSMUSG00000032437

UniProt

Q8TCJ2

Q3TDQ1

RefSeq (mRNA)

NM_178862

NM_024222

RefSeq (protein)

NP_849193

NP_077184

Location (UCSC)Chr 3: 31.53 – 31.64 MbChr 9: 115.07 – 115.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3B is an enzyme that in humans is encoded by the STT3B gene.[5][6][7]

Function

The STT3B protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), STT3B is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation.[8][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163527 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (July 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
  6. ^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.
  7. ^ a b "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".
  8. ^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8). Springer Science and Business Media LLC: 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Shibatani T, David LL, McCormack AL, Frueh K, Skach WR (April 2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
  • v
  • t
  • e