Rodopsin kinaza

Rodopsin kinaza
Identifikatori
EC broj 2.7.11.14
CAS broj 54004-64-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
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PubMed articles
NCBI Protein search

Rodopsin kinaza (EC 2.7.11.14, kupasti opsin kinaza, G-protein-spregnuti receptor kinaza 1, GPCR kinaza 1, GRK1, GRK7, opsinska kinaza, opsinska kinaza (fosforilacija), rodopsinska kinaza (fosforilacija), RK, STK14) je enzim sa sistematskim imenom ATP:rodopsin fosfotransferaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + rodopsin ⇌ {\displaystyle \rightleftharpoons } ADP + fosforhodopsin

G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).

Reference

  1. ↑ Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. (1986). „Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase”. Nature 321: 869-872. PMID 3014340. 
  2. ↑ Shichi, H. and Somers, R.L. (1978). „Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase”. J. Biol. Chem. 253: 7040-7046. PMID 690139. 
  3. ↑ Palczewski, K., McDowell, J.H. and Hargrave, P.A. (1988). „Purification and characterization of rhodopsin kinase”. J. Biol. Chem. 263: 14067-14073. PMID 2844754. 
  4. ↑ Weller, M., Virmaux, N. and Mandel, P. (1975). „Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin”. Proc. Natl. Acad. Sci. USA 72: 381-385. PMID 164024. 
  5. ↑ Cha, K., Bruel, C., Inglese, J. and Khorana, H.G. (1997). „Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications”. Proc. Natl. Acad. Sci. USA 94: 10577-10582. PMID 9380677. 
  6. ↑ Khani, S.C., Abitbol, M., Yamamoto, S., Maravic-Magovcevic, I. and Dryja, T.P. (1996). „Characterization and chromosomal localization of the gene for human rhodopsin kinase”. Genomics 35: 571-576. PMID 8812493. 
  7. ↑ Chen, C.K., Zhang, K., Church-Kopish, J., Huang, W., Zhang, H., Chen, Y.J., Frederick, J.M. and Baehr, W. (2001). „Characterization of human GRK7 as a potential cone opsin kinase”. Mol. Vis. 7: 305-313. PMID 11754336. 
  8. ↑ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626-633. PMID 14654303. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

  • MeSH Rhodopsin+kinase